The effect of relative humidity and formulation variables on chewable xylitol-sorbitol tablets

Abstract Changing relative humidity levels challenge the manufacturing of chewable xylitol-sorbitol based tablets. The aim study is to investigate how formulation tablets affects properties powder blends and in an environment different levels. In all, 30 batches containing ratios sorbitol, xylitol magnesium stearate were prepared at three Powder made into using instrumented eccentric tableting machine. To demonstrate effect variables on blend tablet properties, multiple linear regression analysis was performed. It found that benefitted from large amount stearate, high lubricant level negatively affected quality only humidity. presence environmental humidity, sorbitol mixture must be limited order prevent sticking whereas low higher content needed decrease friability Results indicate alternating truly production if not controllable, there a need for additional filler-binders.